Pipeline
Ethris’ wholly owned pipeline comprises first- or best-in-class mRNA-based product candidates for treatment of asthma and rare pulmonary diseases. The versatility of our technology platform enables us to address an array of diverse diseases with unmet medical needs.
Pipeline Program Overview
Disease indications
Asthma
Uncontrolled asthma is a significant burden for patients as ~50% of moderate and sever asthma patients are classified as uncontrolled despite current medication. In the US these are 4.4M patients suffering from asthma attacks leading to 1 million annual emergency department visits & 100 thousand inpatien stays. 80% of acute asthma attacks are associated with virus infections with ETH47 being a first-in class therapy correcting low interferon lambda levels ins asthmatics to prevent asthma attacks driven by viruses.
Protein Replacement Therapies
Primary Ciliary Dyskinesia (PCD)
Primary Ciliary Dyskinesia (PCD) is a rare disease that arises from structural defects or the absence of the cilia lining our respiratory tract. With the cilia unable to function, mucus loaded with trapped microbes, dust, and other debris cannot be cleared from the airways efficiently and can often lead to permanent lung damage. With our SNIM®RNA technology we can deliver a corrected mRNA that is designed to produce ciliary proteins in the respiratory tract thereby reconstituting cilia function.
